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Background/Objectives: The broad spectrum of clinical manifestations from SARS-COV-2 infection and observed risk factors for severe disease highlight the importance of understanding molecular mechanisms underlying SARS-CoV-2 associated disease pathogenesis. Research studies have identified a large number of host proteins that play roles in viral entry, innate immune response, or immune signalling during infection. The ability to interrogate subsets of these genes simultaneously within SARSCOV-2 infected samples is critical to understanding how their expression contribute to phenotypic variability of the disease caused by the pathogen. Method(s): 30 Nasopharyngeal swab were obtained and included SARS-CoV-2 infected and control samples. RNA was extracted, reverse transcribed and loaded onto flexible TaqMan array panels designed specifically for targeting the most cited genes related to SARS-COV-2 entry and restriction factors as well as cytokines, chemokines, and growth factors involved in the pathogenesis. Result(s): Our data indicated that not only were the levels of several of these host factors differentially modulated between the two study groups, but also that SARS-CoV-2 infected subjects presented with greater frequency of several important inflammatory cytokines and chemokines such as CCL2, CCL3, IFNG, entry receptors such as ACE2, TMRPS11A, and host restriction factors including LY6E and ZBP1. Conclusion(s): TaqMan array plates provide a fast, midthroughput solution to determine the levels of several virus and host-associated factors in various cell types and add to our understanding of how the pathogenesis may vary depending on gender, age, infection site etc.
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Recent advancements in nanotechnology have resulted in improved medicine delivery to the target site. Nanosponges are three-dimensional drug delivery systems that are nanoscale in size and created by cross-linking polymers. The introduction of Nanosponges has been a significant step toward overcoming issues such as drug toxicity, low bioavailability, and predictable medication release. Using a new way of nanotechnology, nanosponges, which are porous with small sponges (below one microm) flowing throughout the body, have demonstrated excellent results in delivering drugs. As a result, they reach the target place, attach to the skin's surface, and slowly release the medicine. Nanosponges can be used to encapsulate a wide range of medicines, including both hydrophilic and lipophilic pharmaceuticals. The medication delivery method using nanosponges is one of the most promising fields in pharmacy. It can be used as a biocatalyst carrier for vaccines, antibodies, enzymes, and proteins to be released. The existing study enlightens on the preparation method, evaluation, and prospective application in a medication delivery system and also focuses on patents filed in the field of nanosponges.Copyright © 2023 The Authors.
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The World Health Organization (WHO) declared an international public health concern on January 30, 2020, in response to the idiopathic Coronavirus disease 2019 (COVID-19) pandemic outbreak. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of the disease being identified as the third human Coronavirus, was discovered in Wuhan, Hubei Province, China. Coronavirus belongs to the Coronaviridae family, Coronavirinae subfamily which according to their genetic structures, are grouped into alphaCoronavirus (aCoV), betaCoronavirus (bCoV), gamma Corona¬virus (yCoV) and deltaCoronavirus (dCoV) of order Nidovirales. Coronaviruses are enveloped, positive-sense, single-stranded RNA viruses invading a wide variety of host species. SARS-CoV-2 belongs to extensively. Angiotensin¬converting enzyme 2 (ACE2) is imperative for Novel SARS-CoV-2 to enter host cells as a substrate receptor. With a high mortality rate in the elderly, immune-compromised, diabetic, and patients with cardiovascular and respiratory diseases, COVID-19 is an extremely contagious disease. Patients who are afflicted experience fever, a nonproductive cough, lethargy, dyspnea, and occasionally diarrhoea as well as radiographic signs of pneumonia. A cytokine storm is a result of the immune system's aggressive response to a virus that has propagated inside the body. Genetic recombination and mutation are the main drivers of the emergence of novel SARS-CoV-2 variants. Variants of concern (VOCs) are used to describe some variants having significant virulence and transmission rates, such as the Omicron variants now. RT-LAMP, RT- qPCR, and High-Resolution Computed Tomography, among other new cutting-edge techniques, are effective at diagnosing SARS-CoV-2 infected patients. Standard treatments involving compounds like Lopinavir/Ritonavir, paxlovid, and molnupiravir have shown to be efficacious to some extent against even the newly emerging strains when it comes to treatment approaches. Additionally, immunization is a crucial strategy for preventing the disease or lessening its impact. Live attenuated vaccines, DNA- and RNA-based vaccines, protein subunit vaccines, and amplifying viral vector vaccines are among the molecular frameworks used in the production of vaccines against SARS-CoV-2. Comirnaty by Pfizer-BioNTech, SpikeVax by Moderna, and Vaxzevria by Oxford- AstraZeneca are three extensively incorporated and validated COVID-19 vaccines. In a similar vein, a variety of vaccinations have been created with varying degrees of potency against VOCs. Nanotechnology and artificial intelligence (AI) advancements may help in the provision of an effective and dependable remedy for the eradication of SARS-CoV-2. Definitive diagnosis, community engagements, and united scientific approaches have effectively addressed public health issues amid the pandemic. Although COVID-19 has presented a significant challenge to the healthcare system, it has also provided a chance for the development of novel and creative roles that could have significant effects on the healthcare system. This pandemic has highlighted the value of prompt diagnosis, the value of universal healthcare as well as the need for cutting-edge methods to contain pandemics around the world. © 2023 Nova Science Publishers, Inc. All rights reserved.
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Online news and information sources are convenient and accessible ways to learn about current issues. For instance, more than 300 million people engage with posts on Twitter globally, which provides the possibility to disseminate misleading information. There are numerous cases where violent crimes have been committed due to fake news. This research presents the CovidMis20 dataset (COVID-19 Misinformation 2020 dataset), which consists of 1,375,592 tweets collected from February to July 2020. CovidMis20 can be automatically updated to fetch the latest news and is publicly available at: https://github.com/everythingguy/CovidMis20. This research was conducted using Bi-LSTM deep learning and an ensemble CNN+Bi-GRU for fake news detection. The results showed that, with testing accuracy of 92.23% and 90.56%, respectively, the ensemble CNN+Bi-GRU model consistently provided higher accuracy than the Bi-LSTM model. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
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Vaccine hesitancy was found to be one of the top ten global health threats in 2019 by World Health Organization. Worldwide, more than 90% of countries have encountered vaccine hesitancy, which has notably jeopardized the implementation of vaccination campaigns. Some of the factors associated with COVID-19 vaccine hesitancy can be lack of confidence in information or lack of adequate information about the vaccine, misinformation from social media, and a fear of side effects. Widespread acceptance of COVID-19 vaccines is extremely crucial in order to achieve sufficient immunization coverage to end this global pandemic. It is evident that the number of studies that have investigated COVID-19 vaccination attitudes in lower-income countries like India is quite low. We analyze COVID-19 vaccine acceptance and hesitancy in Indian Scenario using the Twitter social media platform to ensure that these vaccines reach even the remotest of places, whether rural or urban, in India, while observing the results and outcomes of our research. We aim for accurate results and hope to help the Indian government in the process of making informed decisions for the vaccine-hesitant groups of India. © 2023 selection and editorial matter, Dr. R. Dhaya and Dr. R. Kanthavel;individual chapters, the contributors.
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The Blood Bank mobile application is an effort of easing the process of receiving and donating blood. This application helps the users to seamlessly donate and receive the required blood and also gives the availability of oxygen and ambulance in nearby hospitals. It gives the user information related to the availability of blood types in different hospitals and blood banks. Taking in mind the COVID-19 pandemic situation, in which the requirement for blood and oxygens were reached an unmanageable level. Blood and Oxygen is an essential part of the healthcare system. Day by day, the requirement for blood and oxygen is increasing, but still, there is unavailability and shortage. This project aims to give people a single platform to resolve these issues. © 2023 IEEE.
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With Covid-19, a significant proportion of the population who are already vaccinated have tested positive. Therefore, there is a need for better medicines that act against the virus rigorously without causing any side effects. We aim to achieve the same through molecular docking and further simulations for bioactive phytochemicals of ayurvedic medicinal plants. The target for this study has been considered the NSP3 protein of the viral RNA that actively takes part in both replication and immune evasion pathways of the virus. Ligand libraries consisting of bioactive phytochemicals of aswasgandha and analogues of curcumin and piperine are curated. The libraries, along with the NSP3 protein moiety are docked onto two active sites. With the best-scored complexes further taken up for molecular dynamics simulation, the study resulted in favourable outcomes for three such ligands (compound ID 5469426, 69501714, ZINC000003874317). © 2023 Bharati Vidyapeeth, New Delhi.
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Multiple stressors such as apprehension of climate change, the anxiety of living in polluted cities, and the dread of COVID-19 are affecting the tranquility and stability of human existence. People are in "isolation” in one form or the other-whether virtually "confined” within a hazy shell of anxiety or literally in self-quarantine to escape from a deadly virus. People who are already experiencing some kind of mental ailment as well as those who do not have any past record of such illness, are both experiencing mental trauma that may range from just feeling sad to having more intense bouts of anxiety and depression. Ecocentrism could perhaps provide an answer to such afflictions. Identifying with Nature might enable people to emerge from the stranglehold of loneliness and move into the tranquil realm of solitude. Thus, one would remain alone, but with a difference. A green reading of ecocentric poetry could provide the key. This chapter aims to delve into this domain, studying poets from diverse parts of the world, and writing in different languages. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
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PurposeCOVID-19 disrupted the lives of consumers across the globe, and the retail sector has been one of the hardest hits. The impact of COVID-19 on consumers' retail choice behaviour and retailers' responses has been studied in detail through multiple lenses. Now that the effect of COVID-19 is abating, there is a need to consolidate the learnings during the lifecycle of COVID-19 and set the agenda for research post-COVID-19.Design/methodology/approachScopus database was searched to cull out academic papers published between March 2020 and June 6, 2022, using keywords;shopping behaviour, retailing, consumer behaviour, and retail channel choice along with COVID-19 (171 journals, 357 articles). Bibliometric analysis followed by selective content analysis was conducted.FindingsCOVID-19 was a black swan event that impacted consumers' psychology, leading to reversible and irreversible changes in retail consumer behaviour worldwide. Research on changes in consumer behaviour and consumption patterns has been mapped to the different stages of the COVID-19 lifecycle. Relevant research questions and potential theoretical lenses have been proposed for further studies.Originality/valueThis paper collates, classifies and organizes the extant research in retail from the onset of the COVID-19 pandemic. It identifies three retail consumption themes: short-term, long-term reversible and long-term irreversible changes. Research agenda related to the retailer and consumer behaviour is identified;for each of the three categories, facilitating the extraction of pertinent research questions for post-COVID-19 studies.
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Introduction: Interventions that try to alter behaviour in order to promote health and disease management are typically time and resource-consuming. At the moment, boosting maternal and child nutrition is the main focus of nutrition programs in India. This paper discusses the most effective methods to change eating habits, hygiene, and sanitisation particularly the significance of contemporary Information Technology (IT) in health education.Aim: To determine the pre education knowledge level and create awareness regarding maternal nutrition, hygiene and sanitation through the developed education video on personal hygiene and sanitation among maternal-aged group women.Materials and Methods: The community-based prospective interventional study was conducted from October 2019 to April 2021 by using the prospective intervention study design. Based on the Socio-demographic profile, anthropometric measurement, and clinical assessment, specific questions regarding dietary knowledge and personal hygiene were recorded by using the questionnaire. By using the recorded data through a questionnaire, 100 respondents were selected through stratified random sampling and divided into the control group (n=50) and experimental group (n=50) involved in the intervention study. The experimental group which consisted of 50 respondents was grouped into two groups E1 (n=25) and E2 (n=25) and educated separately (due to COVID-19 restriction on mass gatherings) three times a month at 15 days intervals. The nutrition education intervention was given through an educational video in the Hindi language. The effects of the intervention were studied among the participants of the experimental group. The control group did not receive any nutritional awareness sessions. Knowledge level before and after the education intervention was recorded by using the self-structured questionnaire consisting of 15 multiple questions. The data was analysed by using Analysis of variance (ANOVA) technique.Results: Analysis was done for the complete data collected from 100 participants (15-35 years of age, 50 in each control and experimental group) included in the present study. The mean age of maternal age group women was 22 years. No significant difference was found between the knowledge of the control and experimental group at baseline (p-value >0.05). However, the post-intervention, there was significant gain in knowledge in the experimental group (p-value <0.001).Conclusion: It was found that providing the nutrition education through the developed information and communication technology proved effective by increasing knowledge level among the maternal aged group women.
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This paper studies three types of leadership theories - value-based leadership, indigenous leadership, and leadership theories with traces of mysticism. The author shows how Sufism can be viewed as a framework of leadership (Spiller and Watson, 2021) that holds a sustained relevance in enduring turbulent times. The paper is timely because of increased interest in positive leadership, values-based leadership and culturally rooted leadership. This paper extends leadership literature in multiple ways. First, it brings to light the relevance of a mystic critique of Sufism built on love in the contemporary situation and is the first work to present Sufism as a different way of leadership. Second, it synchronises with the rising voice of scholars who suggest that leadership studies, devoid of context, are incomplete and that non-western models of leadership must emerge (Sudhakar, 2021;Mango, 2018). Third, it addresses the concern of scholars who have been imploring for taking leadership beyond the realms of logic and including more elements of mysticism (van Lingen, 2019). Finally, future possible research directions are discussed.
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Improved diagnostics aided by AI and bioinformatics tools are playing a significant role in contributing to the ongoing coronavirus disease 2019 (COVID-19) pandemic. These has also improved the understanding of virology of other infectious viral particles such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The undying efforts of the scientific community of various streams including the medicine, biology, public health, bioinformatics, and computer science have resulted in the rapid development of several tools and techniques for diagnosis. These efforts have resulted in high-throughput technologies such as Next-Generation Sequencing for detecting the genome of SARS-CoV-2, databases storing SARS-CoV-2 genomes and variants, bioinformatics software tools, and databases to analyze and store host-virus interactions were developed. These developments have also led to giving an impetus to therapeutics action plans due to identification of COVID-19 biomarkers. This has also paved the path for bioinformatics strategies for drug repurposing to combat this dreadful infection. This chapter focuses on the various bioinformatics and computational tools developed and used in COVID diagnosis. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
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In South Asia, cattle are afflicted by the expanding virulent condition known as Lumpy Skin Disease (LSD), and sheep pox and goat pox are caused by the Capri virus. These illnesses endanger worldwide trade. Due to inadequate immunisations and poverty in rural areas, Capricorn poxviruses are spreading. This is due to the economic repercussions of the COVID-19 epidemic, debilitating sanctions in endemic countries, a growth in the legal and criminal trade of live animals and animal products, and global climate change. Skin spores are the main route of infection;however, the virus is also excreted through bodily fluids and semen. As a result, the virus is transmitted to susceptible hosts by biting flies, mosquitoes, and other insects. Insects can be transstadial and transovarial. Lumpy skin disease lesions can swell and rupture after 7 to 14 days in experimental settings, but it usually takes 2 to 5 weeks in a normal infection. Lumpy skin disease is characterised by hard, constrictive, few (mild forms) to numerous (severe forms) skin nodules that may encompass respiratory, urogenital, and other organ mucous membranes. Consequently, milk output decreases, and in countries that raise cattle, there are more abortions, cases of temporary or permanent infertility, hide damage, and mortality, all of which result in a financial loss. The best method for limiting the spread and monetary impacts of lumpy skin disease is mass immunisation and other management measures. This review provides the latest information on lumpy skin disease's viral biology, transmission, clinical, and pathological aspects. © 2023 Journal of medical pharmaceutical and allied sciences. All rights reserved.
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Sleep is counted as one of the three pillars of a body. Any disruption from normal sleep pattern affects physical, mental and emotional wellbeing. Kapha Dosha is responsible for sound sleep and aggravation of Vata and Pitta Dosha is responsible for Anidra. Shirodhara therapy is among the widely prescribed Panchakarma procedures for the treatment of Anidra. This is a case of a thirty-six years old male patient who was suffering from difficulty in falling and staying asleep along with associated complaints like excessive yawning, drowsiness, giddiness, heaviness in the head, body stiffness and indigestion for a year. Covid 19 pandemic acted as a stress trigger in the patient. Signs of any other systemic illness were absent. The patient was treated with Shirodhara with Ksheerbala oil for fourteen days. The insomnia severity index score reduced from 15 to 5 after treatment and the associated symptoms grading score reduced from ten points to two points. Shirodhara therapy not only reduced insomnia severity index score but also improved the quality of sleep and provided relief to associated complaints.
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In social IoMT systems, resource-constrained devices face the challenges of limited computation, bandwidth, and privacy in the deployment of deep learning models. Federated learning (FL) is one of the solutions to user privacy and provides distributed training among several local devices. In addition, it reduces the computation and bandwidth of transferring videos to the central server in camera-based IoMT devices. In this work, we design an edge-based federated framework for such devices. In contrast to traditional methods that drop the resource-constrained stragglers in a federated round, our system provides a methodology to incorporate them. We propose a new phase in the FL algorithm, known as split learning. The stragglers train collaboratively with the nearest edge node using split learning. We test the implementation using heterogeneous computing devices that extract vital signs from videos. The results show a reduction of 3.6 h in the training time of videos using the split learning phase with respect to the traditional approach. We also evaluate the performance of the devices and system with key parameters, CPU utilization, memory consumption, and data rate. Furthermore, we achieve 87.29% and 60.26% test accuracy at the nonstragglers and stragglers, respectively, with a global accuracy of 90.32% at the server. Therefore, FedCare provides a straggler-resistant federated method for a heterogeneous system for social IoMT devices.
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Guest loyalty has great effect on their satisfaction as well as it helps to increase the efficiency, and it leads to improved profit and sale of hotel and create positive impact on customers. Loyalty is a long-Term commitment which helps to stand the business in market for a long time and make business successful. Hospitality industry is the one of the fastest and largest job generating and revenue generating industry in among all sectors. In hospitality industry, employees come with the contact with guest either in front of the house (Front Office F and B service) or back of the house (Food Production Housekeeping) and perform their duties in the best professional way. Customer satisfaction is one of the important objectives to sustain the guest loyalty for repetition. In this research primary data was collected and it belongs to empirical research. Data were collected from the UttrakahndGarhwal region and the major cities covered are Mansoori, Dehradun, Rishikesh and Haridwar. The findings of this study are how customer retention/loyalty relates to the recommendation to the others in addition with the overall outlets performance. The study defines the impact of the overall behavioral variables related to F and B outlets in relation to the satisfaction. The research was conducted with the help of online offline filled questionnaires with the population size of 110. The population covered the regular travelers who have visited any of the Hotels and stayed at least for one night. The data was analyzed by using correlation, ANOVAs and T-Test. The study has reflected the Gap in constraint of the data collection and the COVID-19 Government guidelines. © 2022 IEEE.
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This is the second part of a two-part series article. Recently, we have been in the middle of a difficult time due to the Covid-19 pandemic. Pandemics or global epidemics are not new to humankind;they have occurred many times in history. The discourse of epidemiology describes mainly the causal factors which need to be mitigated to prevent or combat the effects of epidemics. In epidemiology, we are not concerned for a person, but rather every individual globally, to make life healthier for all. In this article, we will discuss the basics of epidemiological practice that scientists have used for centuries to prevent epidemics with great results. Overall, we plan for better global health aided by epidemiology. © 2023, Indian Academy of Sciences.